Tofacitinib uptake by patient-derived intestinal organoids predicts individual clinical responsiveness.

Kyung Ku JangDefne ErcelenJing Yu Carolina Cen FengSakteesh GurunathanChaoting ZhouAryeh KormanLuke NewellDavid HudesmanDrew R JonesP'ng LokeJordan E AxelradKen Cadwell

Published in: bioRxiv : the preprint server for biology (2024)

Patient-derived intestinal organoids predict and identify mechanisms of individual tofacitinib responsiveness in UC. Specifically, MATE1 expression predicted clinical response to tofacitinib.

Keyphrases

rheumatoid arthritis
ulcerative colitis
poor prognosis
binding protein