The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial.
Jamie W BellingeRoslyn J FrancisSing C LeeNicola P BondonnoMarc SimJoshua R LewisGerald F WattsCarl J SchultzPublished in: The American journal of clinical nutrition (2021)
In individuals with diabetes mellitus, supplementation with 10 mg vitamin K1/d may prevent the development of newly calcifying lesions within the aorta and the coronary arteries as detected using 18F-NaF PET. Further long-term studies are needed to test this hypothesis.This trial was registered at anzctr.org.au as ACTRN12616000024448.
Keyphrases
- double blind
- phase iii
- pet ct
- phase ii
- study protocol
- placebo controlled
- clinical trial
- open label
- coronary artery
- glycemic control
- coronary artery disease
- pulmonary artery
- aortic valve
- positron emission tomography
- chronic kidney disease
- computed tomography
- sensitive detection
- randomized controlled trial
- type diabetes
- reduced graphene oxide
- case control
- heart failure
- aortic stenosis
- pet imaging
- pulmonary arterial hypertension
- skeletal muscle
- atrial fibrillation
- insulin resistance
- ejection fraction
- weight loss