Vitronectin-derived bioactive peptide prevents spondyloarthritis by modulating Th17/Treg imbalance in mice with curdlan-induced spondyloarthritis.

Hong-Ki MinJeongWon ChoiSeon-Yeong LeeA Ram LeeByung-Moo MinMi-La ChoSung Hwan Park

Published in: PloS one (2022)

VnP-16 plus celecoxib prevented SpA progression in a mouse model by regulating the Th17/Treg imbalance and suppressing the expression of proinflammatory cytokines.

Keyphrases

mouse model
ankylosing spondylitis
disease activity
signaling pathway
poor prognosis
high glucose
diabetic rats
rheumatoid arthritis
systemic lupus erythematosus
high fat diet induced
type diabetes
long non coding rna
skeletal muscle
insulin resistance
stress induced