A medium-chain fatty acid analogue prevents hepatosteatosis and decreases inflammatory lipid metabolites in a murine model of parenteral nutrition-induced hepatosteatosis.

Bennet S ChoScott C FligorGillian L FellJordan D SecorSavas T TsikisAmy PanLumeng J YuVictoria H KoDuy T DaoLorenzo Anez-BustillosThomas I HirschJenny LundArild C RustanDavid A FraserKathleen M GuraMark Puder

Published in: PloS one (2023)

SEFA-6179 treatment prevented hepatosteatosis and decreased toxic lipid metabolites in a murine model of parenteral nutrition-induced hepatosteatosis. An increase in both β- and complete hepatic fatty acid oxidation may underlie the reduction in steatosis.

Keyphrases

fatty acid
high glucose
diabetic rats
ms ms
oxidative stress
insulin resistance
endothelial cells
high fat diet
type diabetes
hydrogen peroxide
metabolic syndrome
nitric oxide
skeletal muscle