A novel distyryl boron dipyrromethene with two functional tags for site-specific bioorthogonal photosensitisation towards targeted photodynamic therapy.

Xuejiao GuoRoy C H WongYimin Zhou Dennis K P Ng Pui-Chi Lo

Published in: Chemical communications (Cambridge, England) (2019)

A distyryl boron dipyrromethene based photosensitiser substituted with 1,2,4,5-tetrazine and alkyne moieties was prepared. Through site-specific bioorthogonal reactions with the complementary functional tags anchored on the membrane of A431 human epidermoid carcinoma cells, this versatile photosensitiser exhibited enhanced cellular uptake and photocytotoxicity. The bioorthogonal ligation was also demonstrated in tumour-bearing nude mice.

Keyphrases

photodynamic therapy
endothelial cells
molecular docking
cancer therapy
high fat diet induced
induced pluripotent stem cells
type diabetes
metabolic syndrome
skeletal muscle
drug delivery
pluripotent stem cells
adipose tissue