Titanium Carbide MXene Quantum Dots-Modified Hydroxyapatite Hollow Microspheres as pH/Near-Infrared Dual-Response Drug Carriers.
Miaomiao LiuXiaosen PanYuanjing GanMeng GaoXinran LiZhen LiuXiaojun MaMengru GengXiangqi MengNing MaJie LiPublished in: Langmuir : the ACS journal of surfaces and colloids (2023)
Titanium carbide MXene quantum dots (MQDs) possess intrinsic regulatory properties and selective toxicity to cancer cells. Here, MDQs were selected for the modification of hydroxyapatite (HA) microspheres, and MXene quantum dots-modified hydroxyapatite (MQDs-HA) hollow microspheres with controllable shapes and sizes were prepared as bone drug carriers. The results show that the prepared MQDs-HA hollow microspheres had a large BET surface area (231.2 m 2 /g), good fluorescence, and low toxicity. In addition, MQDs-HA showed a mild storage-release behavior and good responsiveness of pH and near-infrared (NIR). Thus, the MQDs-HA hollow microspheres have broad application prospects in the field of drug delivery and photothermal therapy.
Keyphrases
- molecularly imprinted
- quantum dots
- solid phase extraction
- drug delivery
- sensitive detection
- bone regeneration
- energy transfer
- oxidative stress
- lactic acid
- photodynamic therapy
- bone mineral density
- transcription factor
- adverse drug
- cancer therapy
- body composition
- mass spectrometry
- postmenopausal women
- liquid chromatography
- oxide nanoparticles
- soft tissue
- hyaluronic acid