Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation.
Cheri A PaschPeter F FavreauAlexander E YuehChristopher P BabiarzAmani A GilletteJoe T SharickMohammad Rezaul KarimKwangok P NickelAlyssa K DeZeeuwCarley M SpracklingPhilip B EmmerichRebecca A DeStefanisRosabella T PiteraSusan N PayneDemetra P KorkosLinda ClipsonChristine M WalshDevon MillerEvie H CarchmanMark E BurkardKayla K LemmonKristina A MatkowskyjMichael A NewtonIrene M OngMichael F BassettiRandall J KimpleMelissa C SkalaDustin A DemingPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
These studies add to the literature demonstrating feasibility to grow clinical patient-derived organotypic cultures for treatment effectiveness testing. Together, these culture methods and response assessment techniques hold great promise to predict treatment sensitivity for patients with cancer undergoing chemotherapy and/or radiation.