Lipids: An Atomic Toolkit for the Endless Frontier.

The evolution of lipids in nanoscience exemplifies the powerful coupling of advances in science and technology. Here, we describe two waves of discovery and innovation in lipid materials: one historical and one still building. The first wave leveraged the relatively simple capability for lipids to orient at interfaces, building layers of functional groups. This simple form of building with atoms yielded a stunning range of technologies: lubricant additives that dramatically extended machine lifetimes, molecules that enabled selective ore extraction in mining, and soaps that improved human health. It also set the stage for many areas of modern nanoscience. The second wave of lipid materials, still growing, uses the more complex toolkits lipids offer for building with atoms, including controlling atomic environment to control function (e.g., pKa tuning) and the generation of more arbitrary two-dimensional and three-dimensional structures, including lipid nanoparticles for COVID-19 mRNA vaccines.