Exosomes are the novel players involved in the beneficial effects of exercise on type 2 diabetes.
Gaohua LiHua LiuChunlian MaYanfang ChenJinju WangYi YangPublished in: Journal of cellular physiology (2019)
Exosomes contain regulatory signals such as lipids, proteins, and nucleic acids which can be transferred to adjacent or remote cells to mediate cell-to-cell communication. Exercise is a positive lifestyle for metabolic health and a nonpharmacological treatment of insulin resistance and metabolic diseases. Moreover, exercise is a stressor that induces cellular responses including gene expression and exosome release in various types of cells. Exosomes can carry the characters of parent cells by their modified cargoes, representing novel mechanisms for the effects of exercise. Here, we present a review of exosomes as the perspective players in mediating exercise's beneficial impacts on type 2 diabetes (T2D).
Keyphrases
- type diabetes
- induced apoptosis
- high intensity
- mesenchymal stem cells
- physical activity
- insulin resistance
- gene expression
- cell cycle arrest
- stem cells
- resistance training
- cardiovascular disease
- single cell
- metabolic syndrome
- cell therapy
- oxidative stress
- endoplasmic reticulum stress
- glycemic control
- signaling pathway
- dna methylation
- cell death
- risk assessment
- body composition
- social media
- weight loss
- high fat diet
- fatty acid
- human health