Tissue-free liquid biopsies combining genomic and methylation signals for minimal residual disease detection in patients with early colorectal cancer from the UK TRACC Part B study.

Susanna Slater Annette Bryant Maria Aresu Ruwaida Begum Hsiang-Chi Chen Clare Peckitt Retchel Lazaro-Alcausi Paul Carter Gayathri Anandappa Shelize Khakoo Lucinda Melcher Vanessa Potter Francisca M Marti Joseph Huang Graham Branagan Nicol George Muti Abulafi Sarah Duff Ashraf Raja Ashish Gupta Nicholas West Leslie A Bucheit Thereasa A Rich Ian Chau David Cunningham Naureen Starling

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

Tissue-free MRD detection with longitudinal sampling predicts recurrence in stage I-III CRC without need for tissue sequencing. NPV is high supporting ACT de-escalation in patients with ctDNA not detected post-operatively, now being investigated in the UK TRACC Part C study.

Keyphrases

cross sectional
dna methylation
clinical trial
loop mediated isothermal amplification
mass spectrometry
open label
label free
ionic liquid
gene expression
quantum dots
atomic force microscopy
sensitive detection
free survival
high speed
circulating tumor cells
double blind
circulating tumor