T cell infiltration and upregulation of MHCII in microglia leads to accelerated neuronal loss in an α-synuclein rat model of Parkinson's disease.

Meena S SubbarayanCharles HudsonLauren D MossKevin R NashPaula C Bickford

Published in: Journal of neuroinflammation (2020)

These data demonstrate that T cell infiltration and microglial upregulation of MHCII are involved in α-synuclein-mediated DA neuron loss in this rat model of PD.

Keyphrases

inflammatory response
poor prognosis
cell proliferation
neuropathic pain
signaling pathway
lipopolysaccharide induced
big data
lps induced
spinal cord
artificial intelligence
brain injury
deep learning