Trans-arterial chemoembolization as a loco-regional inducer of immunogenic cell death in hepatocellular carcinoma: implications for immunotherapy.

David James PinatoSam M MurrayAlejandro FornerTakahiro KanekoDavid J PinatoPierluigi ToniuttoBeatriz MínguezValentina CacciatoClaudio AvelliniAlba DiazRosemary J BoytonDaniel M AltmannRobert D GoldinAyse U AkarcaTeresa MarafiotiFrancesco A MauriEdoardo CasagrandeFederica GrilloEdoardo GianniniSherrie BhooriVincenzo Mazzaferro

Published in: Journal for immunotherapy of cancer (2022)

TACE is associated with lower IT density of immune-exhausted effector cytotoxic and T-regs, with significant upregulation of pro-inflammatory pathways. This highlights the pleiotropic effects of TACE in modulating the tumor microenvironment and strengthens the rationale for developing immunotherapy alongside TACE.

Keyphrases

cell death
signaling pathway
poor prognosis
cell proliferation
dendritic cells
radiofrequency ablation
cell cycle arrest
type iii