Endothelial-specific Enhancer as a Cis Element of PLAUR Regulation by TNF-alpha, IL-1beta, and VEGF.
Dmitry PenkovIrina B BeloglazovaYelena V ParfyonovaPublished in: Current pharmaceutical design (2024)
The expression of human PLAUR gene, which encodes the urokinase plasminogen activator receptor (uPAR), is cell- and process-specific, elevating inflammation, cancer and senescence. Its tight regulation is achieved by regulatory elements in the gene locus, such as the promoter and several enhancers. The promoter activity is not specific to a particular cell type and has been described earlier. The proximal enhancer is endothelial- specific and responsible for the PLAUR expression pattern in endothelial cells. In this study, we described the enhancer activity and its cis elements based on the published data. We showed a possible connection of the enhancer activity with known cellular phenotypes.
Keyphrases
- endothelial cells
- transcription factor
- binding protein
- poor prognosis
- high glucose
- dna methylation
- vascular endothelial growth factor
- genome wide
- rheumatoid arthritis
- genome wide identification
- oxidative stress
- dna damage
- copy number
- blood brain barrier
- systematic review
- cell therapy
- electronic health record
- bone marrow
- artificial intelligence
- squamous cell
- induced pluripotent stem cells