Nanomaterial-Based Tumor Photothermal Immunotherapy.
Peng XuFeng LiangPublished in: International journal of nanomedicine (2020)
In recent years, photothermal therapy (PTT) particularly nanomaterial-based PTT is a promising therapeutic modality and technique for cancer tumor ablation. In addition to killing tumor cells directly through heat, PTT also can induce immunogenic cell death (ICD) to activate the whole-body anti-tumor immune response, including the redistribution and activation of immune effector cells, the expression and secretion of cytokines and the transformation of memory T lymphocytes. When used in combination with immunotherapy, the efficacy of nanomaterial-based PTT can be improved. This article summarized the mechanism of nanomaterial-based PTT against cancer and how nanomaterial-based PTT impacts the tumor microenvironment and induces an immune response. Moreover, we reviewed recent advances of nanomaterial-based photothermal immunotherapy and discussed challenges and future outlook.
Keyphrases
- immune response
- cell death
- papillary thyroid
- dendritic cells
- photodynamic therapy
- squamous cell
- induced apoptosis
- drug delivery
- cell cycle arrest
- poor prognosis
- cancer therapy
- regulatory t cells
- lymph node metastasis
- toll like receptor
- oxidative stress
- squamous cell carcinoma
- current status
- inflammatory response
- cell proliferation
- heat stress
- endoplasmic reticulum stress
- radiofrequency ablation