The Therapeutic Mechanisms of Mesenchymal Stem Cells in MS-A Review Focusing on Neuroprotective Properties.
Sonia GavassoTorbjørn KråkenesHåkon OlsenElisabeth Claire EvjenthMarie YtterdalJonas Bull HaugsøenChristopher Elnan KvistadPublished in: International journal of molecular sciences (2024)
In multiple sclerosis (MS), there is a great need for treatment with the ability to suppress compartmentalized inflammation within the central nervous system (CNS) and to promote remyelination and regeneration. Mesenchymal stem cells (MSCs) represent a promising therapeutic option, as they have been shown to migrate to the site of CNS injury and exert neuroprotective properties, including immunomodulation, neurotrophic factor secretion, and endogenous neural stem cell stimulation. This review summarizes the current understanding of the underlying neuroprotective mechanisms and discusses the translation of MSC transplantation and their derivatives from pre-clinical demyelinating models to clinical trials with MS patients.
Keyphrases
- multiple sclerosis
- mesenchymal stem cells
- stem cells
- mass spectrometry
- umbilical cord
- clinical trial
- ms ms
- cerebral ischemia
- cell therapy
- blood brain barrier
- bone marrow
- end stage renal disease
- newly diagnosed
- ejection fraction
- white matter
- oxidative stress
- randomized controlled trial
- open label
- phase iii
- double blind