Systematic review and meta-analyses of the role of drinking water sources in the environmental dissemination of antibiotic-resistant Escherichia coli in Africa.
Akeem Ganiyu RabiuAbidemi Joseph MarcusMorufat Oluwatosin OlaitanOlutayo Israel FalodunPublished in: International journal of environmental health research (2024)
Escherichia coli are pathogenic and antibiotic-resistant organisms that can spread to humans through water. However, there is sparse synthesised information on the dissemination of antibiotic-resistant E. coli through drinking water in Africa. This review provides an overview of the environmental spread of antimicrobial-resistant E. coli through drinking water in Africa. We performed a systematic review based on PRISMA guidelines, and 40 eligible studies from 12 countries were identified until June 2023. Four electronic databases (PubMed, Elsevier, AJOL, and DOAJ) were searched. Studies that employed phenotypic tests ( n = 24/40) in identifying the bacterium outstripped those that utilised genome-based methods ( n = 13). Of the 40 studies, nine and five, respectively, assessed the bacterium for antimicrobial resistance (AMR) phenotype and genotype. Multiple antibiotic resistance indices of 0.04-0.1 revealed a low level of antibiotic resistance. The detection of multidrug-resistant E. coli carrying resistance genes in certain water sources suggests that AMR-surveillance expansion should include drinking water.
Keyphrases
- drinking water
- escherichia coli
- meta analyses
- systematic review
- antimicrobial resistance
- health risk
- health risk assessment
- multidrug resistant
- klebsiella pneumoniae
- case control
- randomized controlled trial
- public health
- staphylococcus aureus
- biofilm formation
- gram negative
- dna methylation
- drug resistant
- health information
- clinical practice
- single cell
- pseudomonas aeruginosa
- risk assessment
- life cycle
- deep learning
- label free