Proteomic aging clock (PAC) predicts age-related outcomes in middle-aged and older adults.

Chia-Ling KuoZhiduo ChenPeiran LiuLuke C Pilling Janice C AtkinsRichard H FortinskyGeorge A KuchelBreno S Diniz

Published in: medRxiv : the preprint server for health sciences (2023)

PAC showed robust age-adjusted associations and predictions for all-cause mortality and the onset of various diseases. The diverse hallmark gene sets linked with PAC proteomic age deviation highlight the potential efficacy of geroscience-guided interventions. Further validation is essential to ascertain the use of PAC across different settings.

Keyphrases

physical activity
genome wide
type diabetes
metabolic syndrome
gene expression
adipose tissue
dna methylation
insulin resistance