Trastuzumab-induced upregulation of a protein set in extracellular vesicles emitted by ErbB2-positive breast cancer cells correlates with their trastuzumab sensitivity.
Arik DruckerByong Hoon YooIman Aftab KhanDongsic ChoiLaura MonterminiXiaoyang LiuSanja JovanovicTallal YounisKirill V RosenPublished in: Breast cancer research : BCR (2020)
Upregulation of a protein set in EVs derived from cultured breast tumor cells correlates with tumor cell trastuzumab sensitivity. It is feasible to further evaluate these proteins as biomarkers of metastatic BC trastuzumab response.
Keyphrases
- epidermal growth factor receptor
- metastatic breast cancer
- tyrosine kinase
- breast cancer cells
- poor prognosis
- cell proliferation
- squamous cell carcinoma
- signaling pathway
- small cell lung cancer
- single cell
- amino acid
- endothelial cells
- cell therapy
- diabetic rats
- drug induced
- long non coding rna
- oxidative stress
- small molecule