Survivin modulatory role in autoimmune and autoinflammatory diseases.
Yasamin PahlavanHouman KahrobaNasser SamadiAbbas KarimiKhalil AnsarinAlireza KhabbaziPublished in: Journal of cellular physiology (2019)
Baculoviral IAP repeat containing 5 (BIRC5) gene encodes the important protein as survivin, a multifunctional protein, which is involved in cellular and molecular networks, progression of cell cycle, homeostasis, developmental morphogenesis, and apoptosis. The proximal BIRC5 promoter possesses specific binding sites for key transcription factors such as nuclear factor κB and signal transducer and activator of transcription 3. Upregulation of survivin exacerbates the autoimmune diseases (AIDs) including multiple sclerosis and myasthenia gravis by reducing the activity threshold of survivin-specific cytotoxic T cells. DNA damage along with upregulation or downregulation of survivin have been demonstrated in initiation and pathogenesis of cancers and AIDs. However, detailed mechanism of survivin function in pathogenesis of AIDs is not well understood. This review focuses on the structure, specificity, regulation, and function of survivin in physiologic conditions and pathogenesis of AIDs.
Keyphrases
- nuclear factor
- cell cycle
- multiple sclerosis
- cell proliferation
- dna damage
- transcription factor
- antiretroviral therapy
- oxidative stress
- signaling pathway
- poor prognosis
- toll like receptor
- myasthenia gravis
- dna methylation
- gene expression
- cell death
- small molecule
- dna repair
- long non coding rna
- copy number
- genome wide analysis