Histone demethylase KDM5 regulates cardiomyocyte maturation by promoting fatty acid oxidation, oxidative phosphorylation, and myofibrillar organization.
Manisha DeoghariaLeslye Venegas-ZamoraAkanksha AgrawalMiusi ShiAbhinav K JainKevin J McHughFrancisco AltamiranoAli J MarianPriyatansh GurhaPublished in: Cardiovascular research (2024)
KDM5 inhibition enhances maturation of iPSC-CMs by epigenetically upregulating the expressions of OXPHOS, FAO, and sarcomere genes and enhancing myofibril organization and mitochondrial function.