The Impact of PIK3R1 Mutations and Insulin-PI3K-Glycolytic Pathway Regulation in Prostate Cancer.

Goutam Chakraborty Subhiksha Nandakumar Rahim HiraniBastien NguyenKonrad H Stopsack Christoph KreitzerSai Harisha RajanalaRomina GhaleYing Z Mazzu Naga Vara Kishore Pillarsetty Gwo-Shu Mary LeeHoward I ScherMichael J Morris Tiffany A TrainaPedram RazaviWassim AbidaJeremy C DurackStephen B SolomonMatthew G Vander Heiden Lorelei A Mucci Andreas G WibmerNikolaus SchultzPhilip W Kantoff

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

Our findings describe a novel genomic feature in metastatic prostate cancer and suggest that PIK3R1 alteration may be a key event for insulin-PI3K-glycolytic pathway regulation in prostate cancer.

Keyphrases

prostate cancer
radical prostatectomy
type diabetes
squamous cell carcinoma
small cell lung cancer
machine learning
glycemic control
deep learning
gene expression
adipose tissue
copy number
dna methylation
metabolic syndrome
weight loss