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Site-specific 68 Ga-labeled nanobody for PET imaging of CD70 expression in preclinical tumor models.

Jonatan DewulfTal FlieswasserTim DelahayeChristel VangestelAlan MirandaHans de HaardJulie JacobsEvelien SmitsTim Van den WyngaertFilipe Elvas
Published in: EJNMMI radiopharmacy and chemistry (2023)
Ga]Ga-NOTA-anti-CD70 VHH showed excellent in vivo targeting of CD70 in human cancer xenografts. PET imaging using this radioimmunoconjugate holds promise as a non-invasive method to identify and longitudinally follow-up patients who will benefit most from anti-CD70 therapies.
Keyphrases
  • pet imaging
  • pet ct
  • positron emission tomography
  • endothelial cells
  • nk cells
  • poor prognosis
  • papillary thyroid
  • young adults
  • cell therapy
  • bone marrow
  • deep learning
  • long non coding rna