Special Considerations in the Management of HIV and Viral Hepatitis Coinfections in Liver Transplantation.
Josiah D McCainDavid Maxwell Hunter ChascsaPublished in: Hepatic medicine : evidence and research (2022)
Modern therapies for hepatitis B virus, hepatitis C virus, and human immunodeficiency virus have become so effective that patients treated for these conditions can have normal life-expectancies. Suitable livers for transplantation remain a scarce and valuable resource. As such, significant efforts have been made to expand donation criteria at many centers. This constant pressure, coupled with the increasing effectiveness of antiviral therapies, has meant that more and more patients infected with hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) may be considered appropriate donors in the right circumstances. Patients with these infections are also more likely to be considered appropriate transplantation recipients than in the past. The treatment of HBV, HCV, and HIV after liver transplantation (LT) can be challenging and complicated by viral coinfections. The various pharmaceutical agents used to treat these infections, as well as the immunosuppressants used post-LT must be carefully balanced for maximum efficacy, and to avoid resistance and drug-drug interactions.
Keyphrases
- hepatitis b virus
- human immunodeficiency virus
- hepatitis c virus
- antiretroviral therapy
- liver failure
- hiv positive
- end stage renal disease
- hiv aids
- sars cov
- hiv infected
- chronic kidney disease
- hiv testing
- ejection fraction
- systematic review
- randomized controlled trial
- newly diagnosed
- peritoneal dialysis
- stem cells
- cell therapy
- kidney transplantation
- bone marrow
- quality improvement
- drug induced