Investigation of MicroRNA in Mitochondrial Apoptotic Pathway in Systemic Lupus Erythematosus.
Yu-Jih SuNai-Wen TsaiChia-Te KungHung-Chen WangWei-Che LinChih-Cheng HuangYa-Ting ChangChih-Min SuYi-Fang ChiangBen-Chung ChengYu-Jun LinCheng-Hsien LuPublished in: BioMed research international (2018)
Our study confirmed the hypothesis that these microRNAs were associated with the mitochondrial apoptotic pathway in SLE. miR-150-5pΔCT was positively associated with SLE disease activity and it was negatively correlated with MAVS 70 kD, which may facilitate viral survival and further enhance inflammation. On the other hand, miR-22-3pΔCT and miR-21-5pΔCT, were negatively correlated with caspase-10 levels, which may repress extrinsic apoptosis and increase cell survival.
Keyphrases
- disease activity
- systemic lupus erythematosus
- cell death
- oxidative stress
- rheumatoid arthritis
- image quality
- dual energy
- computed tomography
- rheumatoid arthritis patients
- contrast enhanced
- ankylosing spondylitis
- juvenile idiopathic arthritis
- cell cycle arrest
- induced apoptosis
- positron emission tomography
- anti inflammatory
- endoplasmic reticulum stress
- magnetic resonance imaging
- signaling pathway
- free survival
- pet ct