Evaluation of high-density lipoprotein-bound long non-coding RNAs in subjects with familial hypercholesterolaemia.

Francesco PurrelloGiosiana BoscoAlessandra ScamporrinoStefania Di MauroAgnese FilippelloFrancesco Di Giacomo BarbagalloSalvatore SpampinatoChiara PavanelloAlice OssoliAntonino Di PinoLaura CalabresiFrancesco PurrelloSalvatore Piro

Published in: European journal of clinical investigation (2023)

LncRNA HIF1A-AS2, LASER and LEXIS were transported by HDL; moreover, significant relationships of HDL-lncRNA LEXIS with Lp(a) levels and PWV were found. Our study suggests that HDL-lncRNA LEXIS may be useful to better identify FH subjects with more pronounced vascular damage.

Keyphrases

long non coding rna
high density
poor prognosis
oxidative stress
early onset
endothelial cells
high speed
low density lipoprotein