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Metformin Improves the Prerequisites for FGF21 Signaling in Patients with Type 2 Diabetes.

Anne Kathrine Nissen PedersenLars Christian GormsenSøren NielsenNiels JessenMette Bjerre
Published in: The Journal of clinical endocrinology and metabolism (2023)
Our findings suggest that metformin suppresses the circulating FAP activity and upregulate the expression of FGFR1c and β-klotho for increased FGF21-signalling in adipose tissue thus improving peripheral FGF21-sensitivity.
Keyphrases
  • adipose tissue
  • poor prognosis
  • insulin resistance
  • signaling pathway
  • high fat diet
  • long non coding rna
  • metabolic syndrome