Metformin Improves the Prerequisites for FGF21 Signaling in Patients with Type 2 Diabetes.

Anne Kathrine Nissen Pedersen Lars Christian Gormsen Søren Nielsen Niels Jessen Mette Bjerre

Published in: The Journal of clinical endocrinology and metabolism (2023)

Our findings suggest that metformin suppresses the circulating FAP activity and upregulate the expression of FGFR1c and β-klotho for increased FGF21-signalling in adipose tissue thus improving peripheral FGF21-sensitivity.

Keyphrases

adipose tissue
poor prognosis
insulin resistance
signaling pathway
high fat diet
long non coding rna
metabolic syndrome