Exploring the Practical Applications of Artificial Intelligence, Deep Learning, and Machine Learning in Maxillofacial Surgery: A Comprehensive Analysis of Published Works.

Artificial intelligence (AI), deep learning (DL), and machine learning (ML) are computer, machine, and engineering systems that mimic human intelligence to devise procedures. These technologies also provide opportunities to advance diagnostics and planning in human medicine and dentistry. The purpose of this literature review was to ascertain the applicability and significance of AI and to highlight its uses in maxillofacial surgery. Our primary inclusion criterion was an original paper written in English focusing on the use of AI, DL, or ML in maxillofacial surgery. The sources were PubMed, Scopus, and Web of Science, and the queries were made on the 31 December 2023. The search strings used were "artificial intelligence maxillofacial surgery", "machine learning maxillofacial surgery", and "deep learning maxillofacial surgery". Following the removal of duplicates, the remaining search results were screened by three independent operators to minimize the risk of bias. A total of 324 publications from 1992 to 2023 were finally selected. These were calculated according to the year of publication with a continuous increase (excluding 2012 and 2013) and R 2 = 0.9295. Generally, in orthognathic dentistry and maxillofacial surgery, AI and ML have gained popularity over the past few decades. When we included the keywords "planning in maxillofacial surgery" and "planning in orthognathic surgery", the number significantly increased to 7535 publications. The first publication appeared in 1965, with an increasing trend (excluding 2014-2018), with an R 2 value of 0.8642. These technologies have been found to be useful in diagnosis and treatment planning in head and neck surgical oncology, cosmetic and aesthetic surgery, and oral pathology. In orthognathic surgery, they have been utilized for diagnosis, treatment planning, assessment of treatment needs, and cephalometric analyses, among other applications. This review confirms that the current use of AI and ML in maxillofacial surgery is focused mainly on evaluating digital diagnostic methods, especially radiology, treatment plans, and postoperative results. However, as these technologies become integrated into maxillofacial surgery and robotic surgery in the head and neck region, it is expected that they will be gradually utilized to plan and comprehensively evaluate the success of maxillofacial surgeries.