Precision medicine for prostate cancer-improved outcome prediction for low-intermediate risk disease using a six-gene copy number alteration classifier.
William Lautert-DutraRodolfo Borges Dos ReisJeremy Andrew SquirePublished in: British journal of cancer (2023)
A multiplex 6-gene copy number classifier was used to distinguish between low- or intermediate-risk prostate cancer patients. The study analysed a cohort of 448 patients and previously published datasets from radical prostatectomies. The classifier performs better than conventional stratification methods, is low cost, and can be performed easily in clinical laboratories.
Keyphrases
- copy number
- prostate cancer
- mitochondrial dna
- end stage renal disease
- genome wide
- chronic kidney disease
- ejection fraction
- newly diagnosed
- dna methylation
- peritoneal dialysis
- low cost
- randomized controlled trial
- radical prostatectomy
- prognostic factors
- systematic review
- single cell
- high throughput
- transcription factor
- rna seq
- patient reported