A Meta-Analysis and Systematic Review of the Efficacy of Twice Daily PPIs versus Once Daily for Treatment of Gastroesophageal Reflux Disease.

Hongying Zhang Zhiping Yang Yongquan Shi Yong Quan Shi

Published in: Gastroenterology research and practice (2017)

PPIs BID more effectively improve endoscopic healing rate at week 8 than PPIs QD. But there are no significant differences in symptom relief, 24 h pH monitoring, sustained symptom relief, and endoscopic response at week 4.

Keyphrases

systematic review
gastroesophageal reflux disease
ultrasound guided
physical activity
meta analyses
patient reported
placebo controlled
endoscopic submucosal dissection
randomized controlled trial