Myoglobin-mediated lipid shuttling increases adrenergic activation of brown and white adipocyte metabolism and is as a marker of thermogenic adipocytes in humans.

Lisa ChristenHelen BroghammerInka RapöhnKevin MöhlisChristian StrehlauAleix Ribas-LatreClaudia GebhardtLisa RothKerstin KrauseKathrin LandgrafAntje KörnerKerstin Rohde-ZimmermannAnne HoffmannNora KlötingAdhideb GhoshWenfei SunHua DongChristian WolfrumTienush RassafUlrike B Hendgen-CottaMichael StumvollMatthias BlüherJohn T HeikerJuliane Weiner

Published in: Clinical and translational medicine (2022)

These data demonstrate for the first time a functional relevance of MBs lipid binding properties and establish MB as an important regulatory element of thermogenic capacity in brown and likely beige adipocytes.

Keyphrases

adipose tissue
fatty acid
insulin resistance
electronic health record
transcription factor
high fat diet induced
big data
metabolic syndrome
dna binding
skeletal muscle
data analysis