A GWAS meta-analysis of alpha angle suggests cam-type morphology may be a specific feature of hip osteoarthritis in older adults.
Benjamin G FaberMonika FryszApril E HartleyRaja EbsimCindy G BoerFiona R SaundersJennifer S GregoryRichard M AspdenNicholas C HarveyLorraine SouthamWilliam GilesChristine L Le MaitreJeremy Mark WilkinsonJoyce B J van MeursEleftheria ZegginiTimothy CootesClaudia LindnerJohn P KempGeorge Davey SmithJonathan H TobiasPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2023)
Expected observational associations between AA and related clinical outcomes provided face-validity for the DXA-derived AA measures. Evidence of bidirectional associations between AA and HOA, particularly in the reverse direction, suggests that hip shape modelling secondary to a genetic predisposition to HOA contributes to the well-established relationship between HOA and cam morphology in older adults.