SLC26A9 deficiency causes gastric intraepithelial neoplasia in mice and aggressive gastric cancer in humans.

Xuemei LiuTaolang LiZhiyuan MaBrigitte RiedererDumin YuanJiaxing ZhuYunhua LiJiaxing AnGuorong WenHai JinXiao YangUrsula SeidlerBiguang Tuo

Published in: Cellular oncology (Dordrecht) (2022)

Our data indicate that SLC26A9 deletion in parietal cells is sufficient to trigger gastric metaplasia and the development of neoplastic lesions. In addition, we found that SLC26A9 expression decreases during human gastric carcinogenesis, and that exogenous SLC26A9 expression in GC cells reduces their malignant behavior.

Keyphrases

induced apoptosis
poor prognosis
cell cycle arrest
high grade
electronic health record
type diabetes
machine learning
metabolic syndrome
long non coding rna
cell proliferation
high resolution
mass spectrometry
induced pluripotent stem cells
deep learning
pi k akt
liquid chromatography