Complementary transcriptomic and proteomic analyses reveal the cellular and molecular processes that drive growth and development of Fasciola hepatica in the host liver.
Krystyna CwiklinskiMark W RobinsonSheila DonnellyJohn P DaltonPublished in: BMC genomics (2021)
The migration of immature F. hepatica parasites within the liver is associated with an increase in protein production, expression of signalling pathways and neoblast proliferation that drive their rapid growth and development. The secretion of a defined set of molecules, particularly cathepsin L peptidases, peptidase-inhibitors, saponins, immune-regulators and antioxidants allow the parasite to negotiate the liver micro-environment, immune attack and increasing levels of oxidative stress. This data contributes to the growing F. hepatica -omics information that can be exploited to understand parasite development more fully and for the design of novel control strategies to prevent host liver tissue destruction and pathology.
Keyphrases
- oxidative stress
- single cell
- plasmodium falciparum
- poor prognosis
- signaling pathway
- transcription factor
- machine learning
- electronic health record
- healthcare
- dna methylation
- gene expression
- small molecule
- artificial intelligence
- binding protein
- health information
- big data
- social media
- single molecule
- data analysis
- loop mediated isothermal amplification