Limited Effect of Y Chromosome Variation on Coronary Artery Disease and Mortality in UK Biobank-Brief Report.
Paul R H J TimmersJames F WilsonPublished in: Arteriosclerosis, thrombosis, and vascular biology (2022)
Kin-cohort analysis of the Y chromosome uniquely allows for discoveries in subjects to be validated using family history data. Despite our large sample size, improved models, and parental validation, there is little evidence to suggest cardiovascular risk in UK Biobank is influenced by genetic variation in MSY.
Keyphrases
- coronary artery disease
- cardiovascular events
- copy number
- cross sectional
- electronic health record
- percutaneous coronary intervention
- coronary artery bypass grafting
- risk factors
- heart failure
- cardiovascular disease
- gene expression
- machine learning
- deep learning
- genome wide
- data analysis
- transcatheter aortic valve replacement