CircPPAP2B controls metastasis of clear cell renal cell carcinoma via HNRNPC-dependent alternative splicing and targeting the miR-182-5p/CYP1B1 axis.

Zaosong ZhengXiangbo ZengYuanchao ZhuMengxin LengZhiyong ZhangQiong WangXiaocen LiuSiying ZengYongyuan XiaoChenxi HuShiyu PangTong WangBihong XuPeidan PengFei LiWanlong Tan

Published in: Molecular cancer (2024)

Collectively, our study provides comprehensive evidence that circPPAP2B promotes proliferation and metastasis of ccRCC via HNRNPC-dependent alternative splicing and miR-182-5p/CYP1B1 axis and highlights circPPAP2B as a potential therapeutic target for ccRCC intervention.

Keyphrases

randomized controlled trial
signaling pathway
risk assessment
drug delivery
human health