Gene Expression Alterations in Peripheral Blood Following Sport-Related Concussion in a Prospective Cohort of Collegiate Athletes: A Concussion Assessment, Research and Education (CARE) Consortium Study.

Edward Simpson Jill L Reiter Jie Ren Zhiqi Zhang Kelly Nicole Holohan NudelmanLarry D RiggenMichael D Menser Jaroslaw Harezlak Tatiana M Foroud Andrew J SaykinAlison BrooksKenneth L CameronStefan M DumaGerald McGintySteven RowsonSteven J SvobodaSteven P BroglioMichael A McCreaPaul F PasquinaThomas W McAllisterYunlong Liunull null

Published in: Sports medicine (Auckland, N.Z.) (2023)

Transcriptome signatures in the blood reflect the known pathophysiology of concussion and may be useful for defining the immediate biological response and the time course for recovery. In addition, the identified immune response pathways and changes in immune cell type proportions following a concussion may inform future treatment strategies.

Keyphrases

mild traumatic brain injury
gene expression
high school
peripheral blood
immune response
healthcare
quality improvement
genome wide
dna methylation
palliative care
body composition
single cell
rna seq
dendritic cells
pain management
inflammatory response