Changes in superoxide dismutase 3 (SOD3) expression in periodontal tissue during orthodontic tooth movement of rat molars and the effect of SOD3 on in vitro hypoxia-exposed rat periodontal ligament cells.

Phanchanit JindarojanakulYukiho KobayashiHiroyuki KamimotoYuki NikiAye Chan MyoSirichom SatrawahaKeiji Moriyama

Published in: European journal of orthodontics (2023)

SOD3 plays a role in periodontal tissue remodelling during OTM and in hypoxia-exposed PDL cells through ROS, HIF-1α, and RANKL/OPG pathways. Moreover, SOD3 treatment could attenuate the negative effects of hypoxia on the PDL cells.

Keyphrases

induced apoptosis
cell cycle arrest
oxidative stress
amyotrophic lateral sclerosis
endothelial cells
cell death
cell proliferation
poor prognosis
signaling pathway
dna damage
hydrogen peroxide
long non coding rna
smoking cessation