Empiric Anti-Pseudomonal β-Lactam Monotherapy Versus Fluoroquinolone Combination Therapy in Patients With Hospital-Acquired Pneumonia: A Multicenter Cohort Study With Propensity Score Matching.

Moon Seong Baek Ae Rin Baek Sang-Bum Hong Soohyun Bae Hye Kyeong Park Changwhan Kim Hyun-Kyung Lee Woo Hyun Cho Jin Hyoung Kim Youjin Chang Heung Bum Lee Hyun-Il Gil Beomsu Shin Kwang Ha Yoo Jae Young Moon Jee Youn Oh Kyung Hoon Min Kyeongman Jeonnull null

Published in: Journal of Korean medical science (2023)

Empiric anti-pseudomonal fluoroquinolone combination therapy showed no survival benefit compared to β-lactam monotherapy in patients with HAP. Caution is needed regarding the routine combination of fluoroquinolones in the empiric treatment of HAP patients with a high risk of MDR.

Keyphrases

combination therapy
urinary tract infection
gram negative
multidrug resistant
healthcare
clinical practice
cross sectional
clinical trial
emergency department
open label
double blind
smoking cessation
acute respiratory distress syndrome
community acquired pneumonia
replacement therapy