Macrophage morphology and distribution are strong predictors of prognosis in resected colorectal liver metastases: results from an external retrospective observational study.
Guido CostaCarlo SpositoCristiana SoldaniMichela Anna PolidoroBarbara FranceschiniFederica MarchesiFaizan Daniyal NasirMatteo VirdisAndrea VingianiAna Lleo de NaldaLuca Di TommasoSoumya KothaAlberto MantovaniVincenzo MazzaferroMatteo DonadonGuido TorzilliPublished in: International journal of surgery (London, England) (2023)
This external validation confirms that morphometric characterization of TAMs can serve as a simple readout of their diversity and allows to reliably stratify patient outcomes and predict disease recurrence after hepatectomy for CLMs.