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A phase III study of transdermal granisetron versus oral ondansetron for women with gynecologic cancers receiving pelvic chemoradiation.

Shannon D ArmbrusterBryan M FellmanAnuja JhingranPatricia J EifelAnn H KloppRobert L ColemanLois Michelle RamondettaMichael Frumovitz
Published in: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (2020)
Transdermal granisetron was 82% more like to control CINV than oral ondansetron in the late phase of cycle 1 and performed similarly to oral ondansetron in all other cycles. Transdermal granisetron should be considered an option as prophylactic antiemetic therapy for gynecologic cancer survivors undergoing chemoradiation.
Keyphrases
  • chemotherapy induced
  • phase iii
  • rectal cancer
  • clinical trial
  • locally advanced
  • open label
  • young adults
  • randomized controlled trial
  • endometrial cancer
  • phase ii