Brønsted Acid Mediated Cascade Reaction To Access 3-(2-Bromoethyl)benzofurans.

Stefania PorcuStefania DemuroAlberto LuridianaAndrea CoccoAngelo FrongiaDavid J AitkenFlorence Charnay-PougetRegis GuillotGiorgia SaraisFrancesco Secci

Published in: Organic letters (2018)

A unified protocol for the construction of 3-(2-bromoethyl)benzofurans and 2-(benzofuran-3-yl)ethylamines from bis[(trimethylsilyl)oxy]cyclobutene has been developed. This mild and facile strategy was applied for the synthesis of a series of 5-HT serotonin receptor agonists, underlining its potential for the syntheses of bioactive compounds and natural products.

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