An observational cohort study to investigate the impact of dolutegravir in pregnancy and its obesogenic effects on the metabolic health of women living with HIV and their children: Study protocol.
Elaine J AbramsJennifer JaoHlengiwe P MadlalaAllison ZerbePatrick CatalanoMariana GerschensonJulia H GoedeckeYolanda GombaJami JosefsonIrwin J KurlandJustine LegbedzeGrace A McComseySandisiwe MatyesiniElton MukondaDaniel T RobinsonLandon MyerPublished in: PloS one (2024)
ORCHID will play a pivotal role in defining obesogenic mechanisms and clinical consequences of DTG use in pregnancy in women with HIV and their children. It will provide insights into metabolic disease risk reduction in the context of HIV/DTG, identify intervention targets, and inform public health approaches to diminish chronic metabolic co-morbidities for women and children.
Keyphrases
- public health
- antiretroviral therapy
- pregnancy outcomes
- young adults
- randomized controlled trial
- hiv infected
- hiv positive
- study protocol
- human immunodeficiency virus
- healthcare
- hiv aids
- polycystic ovary syndrome
- hepatitis c virus
- preterm birth
- pregnant women
- hiv infected patients
- metabolic syndrome
- south africa
- climate change
- breast cancer risk
- drug induced
- human health