Isolation and Total Synthesis of PM170453, a New Cyclic Depsipeptide Isolated from Lyngbya sp.
Rogelio FernándezMarta PérezAlejandro LosadaSilvia ReboredoAsier Gómez-San JuanMaría Jesús MartínAndrés FranceschSimon MuntCarmen CuevasPublished in: Marine drugs (2024)
In our continuing search for biologically active new chemical entities from marine organisms, we have isolated a new cyclic depsipeptide, PM170453 ( 1 ), from a cyanobacterium of the genus Lyngbya sp., collected in the Indo-Pacific Ocean. Structure elucidation of the isolated compound was determined by spectroscopic methods including MS, 1 H, 13 C and 2D-NMR. To solve the supply problem for 1 and progress pharmaceutical development, the total synthesis of 1 that involves a total of 20 chemical steps in a convergent process was carried out. Its in vitro cytotoxic activity against four human tumor cell lines, as well as the inhibition of the interaction between the programmed cell death protein 1 PD-1 and its ligand PD-L1 were also evaluated.
Keyphrases
- particulate matter
- air pollution
- endothelial cells
- polycyclic aromatic hydrocarbons
- heavy metals
- mass spectrometry
- multiple sclerosis
- magnetic resonance
- molecular docking
- ms ms
- high resolution
- water soluble
- induced pluripotent stem cells
- protein protein
- pluripotent stem cells
- amino acid
- gram negative
- small molecule
- binding protein
- risk assessment
- molecular dynamics simulations