The lipopolysaccharide-TLR4 axis regulates hepatic glutaminase 1 expression promoting liver ammonia build-up as steatotic liver disease progresses to steatohepatitis.

Maria Mercado-GómezNaroa Goikoetxea-UsandizagaAnnarein J C KerbertLeire Uraga GracianteparalucetaMarina Serrano-MaciáSofia Lachiondo-OrtegaRubén Rodriguez-AgudoClàudia Gil-PitarchJorge SimónIrene González-RecioMarcos F FondevilaPablo Santamarina-OjedaMario F FragaRubén NogueirasJavier de Las HerasRajiv JalanMaría Luz Martínez-ChantarTeresa C Delgado

Published in: Metabolism: clinical and experimental (2024)

Overall, our results suggest that the LPS/TLR4 axis regulates hepatic GLS expression promoting liver ammonia build-up as steatotic liver disease progresses to steatohepatitis.

Keyphrases

inflammatory response
toll like receptor
poor prognosis
immune response
lps induced
binding protein
anaerobic digestion
room temperature
nuclear factor
long non coding rna
liver fibrosis