Risk of head and traumatic brain injuries associated with antidepressant use among community-dwelling persons with Alzheimer's disease: a nationwide matched cohort study.

Heidi TaipaleMarjaana KoponenAntti TanskanenPiia LavikainenReijo SundJari TiihonenSirpa HartikainenAnna-Maija Tolppanen

Published in: Alzheimer's research & therapy (2017)

Antidepressant use was associated with an increased risk of the most severe outcomes, head and brain injuries, in persons with Alzheimer's disease. Antidepressant use should be carefully considered and the association confirmed in future studies.

Keyphrases

major depressive disorder
community dwelling
white matter
resting state
cognitive decline
spinal cord injury
optic nerve
bipolar disorder
functional connectivity
cerebral ischemia
early onset
cross sectional
type diabetes
multiple sclerosis
subarachnoid hemorrhage
drug induced
mild cognitive impairment