Clinical markers of asthma and IgE assessed in parents before conception predict asthma and hayfever in the offspring.
Randi Jacobsen BertelsenM RavaA E CarsinS AccordiniB BenediktsdóttirJ DratvaK A FranklinJ HeinrichM HolmChrister JanssonA JohannessenD L JarvisR JogiB LeynaertD NorbackE R OmenaasC RaherisonJ L Sánchez-RamosV SchlünssenT SigsgaardS C DharmageC SvanesPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2017)
Parental BHR and specific IgE were associated with offspring asthma and hayfever, with the strongest associations observed with clinical assessment before conception as compared to after birth of the child. If the hypothesis is confirmed in other studies, parental disease activity assessed before conception may prove useful for identifying children at risk for developing asthma with hayfever.