Tissue factor release following traumatic brain injury drives thrombin generation.

William Brad HubbardMartha M S SimKathryn E SaatmanPatrick G SullivanJeremy P Wood

Published in: Research and practice in thrombosis and haemostasis (2022)

TF-mediated thrombin generation is time-dependent after injury and TF increases resolve earlier following CHI as compared to CCI. Taken together, these data support a TF-mediated pathway of thrombin generation after TBI and pinpoint TF as a major player in TBI-induced coagulopathy.

Keyphrases

traumatic brain injury
severe traumatic brain injury
neuropathic pain
diabetic rats
big data
electronic health record
mild traumatic brain injury
oxidative stress
spinal cord
machine learning
stress induced
artificial intelligence