Sharing the multidisciplinary clinical approach to peri- and postmenopausal women: A Delphi consensus among Italian gynecologists, endocrinologists, and cardiologists for an integrated and optimal approach to clinical practice.
Nicola ColacurciPasquale Perrone FilardiAntonio ChianteraAnnamaria ColaoPatrizio PasqualettiAndrea LenziPublished in: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (2024)
The experts highlighted comorbidities and hormone deprivation as crucial clinical problems to be evaluated in perimenopausal women, requiring investigation from cardiovascular and endocrinologic perspectives to assess cardiovascular risk, involving the use of BMI, standard blood samples, endocrine-metabolic tests, and lifestyle assessment, particularly in women with higher cardiovascular and metabolic risks candidates for hormone replacement therapy (HRT). The experts also agreed on the benefits of HRT in improving lipid metabolism and reducing insulin resistance, thereby mitigating the metabolic risks associated with menopause. However, this therapy should be tailored considering individual women's comorbidities and thrombotic risk.
Keyphrases
- postmenopausal women
- replacement therapy
- bone mineral density
- polycystic ovary syndrome
- clinical practice
- insulin resistance
- smoking cessation
- metabolic syndrome
- human health
- cardiovascular disease
- body mass index
- mental health
- physical activity
- pregnancy outcomes
- social media
- healthcare
- breast cancer risk
- stem cells
- weight loss
- risk assessment
- mesenchymal stem cells
- fatty acid
- climate change