Metabolic Surgery and Diabesity: a Systematic Review.
Lionel El KhouryElie ChouillardElias ChahineElias SaikalyTarek DebsRadwan KassirPublished in: Obesity surgery (2019)
Bariatric surgery is used to induce weight loss (baros = weight). Evidence has shown that bariatric surgery improves the comorbid conditions associated with obesity such as hypertension, hyperlipidemia, and type 2 diabetes mellitus T2DM. Hence, shifting towards using metabolic surgery instead of bariatric surgery is currently more appropriate in certain subset of patients. Endocrine changes resulting from operative manipulation of the gastrointestinal tract after metabolic surgery translate into metabolic benefits with respect to the comorbid conditions. Other changes include bacterial flora rearrangement, bile acids secretion, and adipose tissue effect. The aim of this systematic review is to examine clinical trials regarding long-term effects of bariatric and metabolic surgery on patients with T2DM and to evaluate the potential mechanisms leading to the improvement in the glycaemic control.
Keyphrases
- weight loss
- bariatric surgery
- minimally invasive
- coronary artery bypass
- roux en y gastric bypass
- systematic review
- obese patients
- glycemic control
- gastric bypass
- adipose tissue
- clinical trial
- type diabetes
- surgical site infection
- weight gain
- blood pressure
- high fat diet
- end stage renal disease
- randomized controlled trial
- ejection fraction
- cardiovascular disease
- physical activity
- newly diagnosed
- percutaneous coronary intervention
- skeletal muscle
- open label
- cardiovascular risk factors
- peritoneal dialysis
- patient reported
- phase iii
- patient reported outcomes
- study protocol