Efficacy and safety of topical isobutylamido thiazolyl resorcinol (Thiamidol) vs. 4% hydroquinone cream for facial melasma: an evaluator-blinded, randomized controlled trial.

Paula Basso Lima Joana Alexandria Ferreira Dias Daniel Pinho Cassiano Ana Cláudia Cavalcante Esposito Luciane Donida Bartoli Miot Ediléia Bagatin Hélio Amarante Miot

Published in: Journal of the European Academy of Dermatology and Venereology : JEADV (2021)

The melasma improvement achieved using 0.2% Thiamidol did not differ from that of 4% hydroquinone cream. Thiamidol can be considered a suitable option for melasma patients with poor tolerability or treatment failure with hydroquinone.

Keyphrases

randomized controlled trial
study protocol
open label
placebo controlled
systematic review
replacement therapy
smoking cessation